| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM610463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2291548 |
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| IC50 | 380±n/a nM |
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| Citation |  Hartz, RA; Ahuja, VT; Sivaprakasam, P; Xiao, H; Krause, CM; Clarke, WJ; Kish, K; Lewis, H; Szapiel, N; Ravirala, R; Mutalik, S; Nakmode, D; Shah, D; Burton, CR; Macor, JE; Dubowchik, GM Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2- J Med Chem66:4231-4252 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM610463 |
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| n/a |
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| Name | BDBM610463 |
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| Synonyms: | BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide | US10774086, Example 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N6O2 |
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| Mol. Mass. | 414.4598 |
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| SMILES | CC1CN(CCO1)c1ccncc1NC(=O)c1ccnn2cc(nc12)-c1ccccc1 |
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| Structure | 
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