| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor subfamily 4 group A member 3 |
|---|
| Ligand | BDBM610463 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2291590 |
|---|
| IC50 | >2000±n/a nM |
|---|
| Citation |  Hartz, RA; Ahuja, VT; Sivaprakasam, P; Xiao, H; Krause, CM; Clarke, WJ; Kish, K; Lewis, H; Szapiel, N; Ravirala, R; Mutalik, S; Nakmode, D; Shah, D; Burton, CR; Macor, JE; Dubowchik, GM Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2- J Med Chem66:4231-4252 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor subfamily 4 group A member 3 |
|---|
| Name: | Nuclear receptor subfamily 4 group A member 3 |
|---|
| Synonyms: | CHN | CSMF | MINOR | Mitogen-induced nuclear orphan receptor | NOR1 | NR4A3 | NR4A3_HUMAN | Neuron-derived orphan receptor 1 | Nuclear hormone receptor NOR-1 | Nuclear receptor subfamily 4 group A member 3 | TEC |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68244.64 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_104477 |
|---|
| Residue: | 626 |
|---|
| Sequence: | MPCVQAQYSPSPPGSSYAAQTYSSEYTTEIMNPDYTKLTMDLGSTEITATATTSLPSIST
FVEGYSSNYELKPSCVYQMQRPLIKVEEGRAPSYHHHHHHHHHHHHHHQQQHQQPSIPPA
SSPEDEVLPSTSMYFKQSPPSTPTTPAFPPQAGALWDEALPSAPGCIAPGPLLDPPMKAV
PTVAGARFPLFHFKPSPPHPPAPSPAGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALES
HPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAA
CQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKE
VVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYC
PTDQAAAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVL
RLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSLNLQSLNLDIQALACLSAL
SMITERHGLKEPKRVEELCNKITSSLKDHQSKGQALEPTESKVLGALVELRKICTLGLQR
IFYLKLEDLVSPPSIIDKLFLDTLPF
|
|
|
|---|
| BDBM610463 |
|---|
| n/a |
|---|
| Name | BDBM610463 |
|---|
| Synonyms: | BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide | US10774086, Example 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22N6O2 |
|---|
| Mol. Mass. | 414.4598 |
|---|
| SMILES | CC1CN(CCO1)c1ccncc1NC(=O)c1ccnn2cc(nc12)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
