| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM50613892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2294577 |
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| IC50 | 4400±n/a nM |
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| Citation |  Gathiaka, S; Palte, RL; So, SS; Chai, X; Richard Miller, J; Kuvelkar, R; Wen, X; Cifelli, S; Kreamer, A; Liaw, A; McLaren, DG; Fischer, C Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods. Bioorg Med Chem Lett84:0 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM50613892 |
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| n/a |
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| Name | BDBM50613892 |
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| Synonyms: | CHEMBL5280882 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H40F2N2O4S |
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| Mol. Mass. | 574.722 |
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| SMILES | OC(=O)C1(CN2C[C@H](CN3CCC(CCS(=O)(=O)c4ccc(F)cc4)CC3)[C@H](C2)c2cccc(F)c2)CCCC1 |r| |
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| Structure | 
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