| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha' |
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| Ligand | BDBM165364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2295954 |
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| IC50 | 62±n/a nM |
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| Citation |  Davis-Gilbert, ZW; Krämer, A; Dunford, JE; Howell, S; Senbabaoglu, F; Wells, CI; Bashore, FM; Havener, TM; Smith, JL; Hossain, MA; Oppermann, U; Drewry, DH; Axtman, AD Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. ACS Med Chem Lett14:432-441 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha' |
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| Name: | Casein kinase II subunit alpha' |
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| Synonyms: | CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2) |
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| Type: | Protein |
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| Mol. Mass.: | 41223.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 350 |
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| Sequence: | MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
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| BDBM165364 |
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| n/a |
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| Name | BDBM165364 |
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| Synonyms: | US8168651, Compound TABLE 16.31 | US9062043, Table 13, Compound 31 | US9062043, Table 20b, Compound 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16FN3O2 |
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| Mol. Mass. | 361.369 |
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| SMILES | OC(=O)c1ccc2c(c1)nc(NCCc1cccc(F)c1)c1ccncc21 |
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| Structure | 
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