| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Casein kinase II subunit alpha' |
|---|
| Ligand | BDBM50614175 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2295954 |
|---|
| IC50 | 19±n/a nM |
|---|
| Citation |  Davis-Gilbert, ZW; Krämer, A; Dunford, JE; Howell, S; Senbabaoglu, F; Wells, CI; Bashore, FM; Havener, TM; Smith, JL; Hossain, MA; Oppermann, U; Drewry, DH; Axtman, AD Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. ACS Med Chem Lett14:432-441 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Casein kinase II subunit alpha' |
|---|
| Name: | Casein kinase II subunit alpha' |
|---|
| Synonyms: | CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41223.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 350 |
|---|
| Sequence: | MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
|
|
|
|---|
| BDBM50614175 |
|---|
| n/a |
|---|
| Name | BDBM50614175 |
|---|
| Synonyms: | CHEMBL5283179 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N7O |
|---|
| Mol. Mass. | 375.427 |
|---|
| SMILES | CCC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C |
|---|
| Structure | 
|
|---|
Search and Browse
