| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 7 |
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| Ligand | BDBM50614239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2296164 |
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| EC50 | 110±n/a nM |
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| Citation |  Dickson, L; Teall, M; Chevalier, E; Cheung, T; Liwicki, GM; Mack, S; Stephenson, A; White, K; Fosbeary, R; Harrison, DC; Brice, NL; Doyle, K; Ciccocioppo, R; Wu, C; Almond, S; Patel, TR; Mitchell, P; Barnes, M; Ayscough, AP; Dawson, LA; Carlton, M; Bürli, RW Discovery of ACS Med Chem Lett14:442-449 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 7 |
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| Name: | Metabotropic glutamate receptor 7 |
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| Synonyms: | GPRC1G | GRM7 | GRM7 protein | GRM7_HUMAN | MGLUR7 | Metabotropic glutamate receptor 7 | metabotropic glutamate 7 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 102262.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14831 |
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| Residue: | 915 |
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| Sequence: | MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
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| BDBM50614239 |
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| n/a |
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| Name | BDBM50614239 |
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| Synonyms: | CHEMBL5272418 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N2O2 |
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| Mol. Mass. | 324.4168 |
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| SMILES | CNC[C@@H](OCC(=O)N1CCCc2ccccc12)c1ccccc1 |r| |
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| Structure | 
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