Reaction Details |
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Target | Cytoplasmic tyrosine-protein kinase BMX |
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Ligand | BDBM50614535 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2297693 |
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IC50 | 1.2±n/a nM |
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Citation | Toenjes, ST; Heydari, BS; Albright, ST; Hazin, R; Ortiz, MA; Piedrafita, FJ; Gustafson, JL Controlling Ibrutinib's Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med Chem Lett14:305-311 (2023) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cytoplasmic tyrosine-protein kinase BMX |
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Name: | Cytoplasmic tyrosine-protein kinase BMX |
Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
Type: | Tyrosine-protein kinase |
Mol. Mass.: | 78030.42 |
Organism: | Homo sapiens (Human) |
Description: | P51813 |
Residue: | 675 |
Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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BDBM50614535 |
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n/a |
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Name | BDBM50614535 |
Synonyms: | CHEMBL5271284 |
Type | Small organic molecule |
Emp. Form. | C26H26N6O2 |
Mol. Mass. | 454.5236 |
SMILES | Cc1cc(Oc2ccccc2)ccc1-c1nn([C@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 |r| |
Structure |
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