Reaction Details | |||
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Target | Tyrosine-protein kinase HCK | ||
Ligand | BDBM50614536 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2297696 | ||
IC50 | 2310±n/a nM | ||
Citation | Toenjes, ST; Heydari, BS; Albright, ST; Hazin, R; Ortiz, MA; Piedrafita, FJ; Gustafson, JL Controlling Ibrutinib's Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med Chem Lett14:305-311 (2023) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase HCK | |||
Name: | Tyrosine-protein kinase HCK | ||
Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 59600.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08631 | ||
Residue: | 526 | ||
Sequence: |
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BDBM50614536 | |||
n/a | |||
Name | BDBM50614536 | ||
Synonyms: | CHEMBL5278149 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H28N6O2 | ||
Mol. Mass. | 468.5502 | ||
SMILES | Cc1cc(Oc2ccccc2)cc(C)c1-c1nn([C@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12 |r,wD:18.19,(1.35,.46,;.58,1.79,;1.37,3.12,;.61,4.46,;1.39,5.78,;2.93,5.76,;3.72,7.09,;5.27,7.08,;6.02,5.73,;5.23,4.4,;3.69,4.43,;-.93,4.47,;-1.71,3.14,;-3.25,3.14,;-.96,1.81,;-1.65,.43,;-.93,-.93,;-2.01,-2.04,;-1.75,-3.56,;-2.85,-4.63,;-2.48,-6.12,;-1,-6.55,;.11,-5.48,;-.26,-3.98,;1.59,-5.89,;1.9,-7.09,;2.7,-4.83,;3.88,-5.17,;-3.38,-1.35,;-4.81,-1.92,;-6.02,-.97,;-5.8,.55,;-4.37,1.12,;-4.2,2.34,;-3.16,.17,)| | ||
Structure |