| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxynucleoside kinase |
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| Ligand | BDBM50200998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422918 (CHEMBL908770) |
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| IC50 | 5700±n/a nM |
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| Citation |  Hernandez, AI; Familiar, O; Negri, A; Rodríguez-Barrios, F; Gago, F; Karlsson, A; Camarasa, MJ; Balzarini, J; Pérez-Pérez, MJ N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem49:7766-73 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Deoxynucleoside kinase |
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| Name: | Deoxynucleoside kinase |
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| Synonyms: | DNK_DROME | Deoxyribonucleoside kinase | Dm-dNK | Multispecific deoxynucleoside kinase | dnk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29092.93 |
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| Organism: | Drosophila melanogaster |
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| Description: | ChEMBL_627484 |
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| Residue: | 250 |
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| Sequence: | MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNV
NGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRR
NGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYL
QELHELHEDWLIHQRRPQSCKVLVLDADLNLENIGTEYQRSESSIFDAISSNQQPSPVLV
SPSKRQRVAR
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| BDBM50200998 |
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| n/a |
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| Name | BDBM50200998 |
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| Synonyms: | 1-[(Z)-4-[1-(4-chlorophenyl)-1,1-(diphenyl)methoxy]-2-buten-1-yl]thymine | CHEMBL373997 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25ClN2O3 |
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| Mol. Mass. | 472.963 |
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| SMILES | Cc1cn(C\C=C/COC(c2ccccc2)(c2ccccc2)c2ccc(Cl)cc2)c(=O)[nH]c1=O |
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| Structure | 
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