| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 4 |
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| Ligand | BDBM50614961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2299494 |
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| IC50 | 268±n/a nM |
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| Citation |  Wang, M; Lan, L; Wang, YW; Zhang, JY; Shi, L; Sun, LP Design, synthesis, and anticancer evaluation of arylurea derivatives as potent and selective type II irreversible covalent FGFR4 inhibitors. Bioorg Med Chem87:0 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 4 |
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| Name: | Fibroblast growth factor receptor 4 |
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| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF |
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| Type: | Protein |
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| Mol. Mass.: | 87957.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22455 |
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| Residue: | 802 |
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| Sequence: | MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
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| BDBM50614961 |
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| n/a |
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| Name | BDBM50614961 |
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| Synonyms: | CHEMBL5266203 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31F3N6O3 |
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| Mol. Mass. | 580.6007 |
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| SMILES | CC#CC(=O)Nc1ccc(Oc2ccc(NC(=O)Nc3ccc(CN4CCN(C)CC4)c(c3)C(F)(F)F)c(C)c2)cn1 |
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| Structure | 
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