Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 11 |
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Ligand | BDBM50546219 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2299542 |
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IC50 | 4.0±n/a nM |
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Citation | Petrocchi, A; Grillo, A; Ferrante, L; Randazzo, P; Prandi, A; De Matteo, M; Iaccarino, C; Bisbocci, M; Cellucci, A; Alli, C; Nibbio, M; Pucci, V; Amaudrut, J; Montalbetti, C; Toniatti, C; Di Fabio, R Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors. ACS Med Chem Lett14:645-651 (2023) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 11 |
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Name: | Tyrosine-protein phosphatase non-receptor type 11 |
Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
Type: | Protein phosphatase |
Mol. Mass.: | 68443.59 |
Organism: | Homo sapiens (Human) |
Description: | Q06124 |
Residue: | 593 |
Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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BDBM50546219 |
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n/a |
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Name | BDBM50546219 |
Synonyms: | CHEMBL4752026 | US11596633, Compound B | US11702392, Compound RMC-4550 |
Type | Small organic molecule |
Emp. Form. | C21H26Cl2N4O2 |
Mol. Mass. | 437.363 |
SMILES | C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N |r| |
Structure |
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