Reaction Details |
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Target | Cyclin-dependent kinase 4 |
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Ligand | BDBM50201227 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_453861 (CHEMBL885863) |
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IC50 | >5000±n/a nM |
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Citation | Boschelli, DH; Barrios Sosa, AC; Golas, JM; Boschelli, F Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of SKS-927. Bioorg Med Chem Lett17:1358-61 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 4 |
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Name: | Cyclin-dependent kinase 4 |
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
Type: | Enzyme Subunit |
Mol. Mass.: | 33731.96 |
Organism: | Homo sapiens (Human) |
Description: | P11802 |
Residue: | 303 |
Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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BDBM50201227 |
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n/a |
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Name | BDBM50201227 |
Synonyms: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile | CHEMBL391738 | SKS-927 |
Type | Small organic molecule |
Emp. Form. | C27H27Cl2N5O2 |
Mol. Mass. | 524.442 |
SMILES | COc1cc(Nc2c(cnc3cc(C#CCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl |
Structure |
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