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TargetDual specificity mitogen-activated protein kinase kinase 7
LigandBDBM31085
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2299692
IC50 260±n/a nM
Citation Kim, DROrr, MJKwong, AJDeibler, KKMunshi, HHBridges, CSChen, TJZhang, XLacorazza, HDScheidt, KA Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett14:606-613 (2023) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 7
Name:Dual specificity mitogen-activated protein kinase kinase 7
Synonyms:Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4
Type:Protein
Mol. Mass.:47502.52
Organism:Homo sapiens (Human)
Description:O14733
Residue:419
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
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  Blast E-value cutoff:
BDBM31085
n/a
NameBDBM31085
Synonyms:1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea | 1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea | 1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea | AST-487 | cid_11409972
TypeSmall organic molecule
Emp. Form.C26H30F3N7O2
Mol. Mass.529.5573
SMILESCCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: