| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Ligand | BDBM50615122 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2299692 |
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| IC50 | 110±n/a nM |
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| Citation |  Kim, DR; Orr, MJ; Kwong, AJ; Deibler, KK; Munshi, HH; Bridges, CS; Chen, TJ; Zhang, X; Lacorazza, HD; Scheidt, KA Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett14:606-613 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 7 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4 |
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| Type: | Protein |
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| Mol. Mass.: | 47502.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14733 |
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| Residue: | 419 |
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| Sequence: | MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
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| BDBM50615122 |
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| n/a |
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| Name | BDBM50615122 |
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| Synonyms: | CHEMBL5267684 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14ClF3N4O2 |
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| Mol. Mass. | 422.788 |
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| SMILES | Fc1ccc(F)c(CNc2cc(Oc3cccc(NC(=O)CCl)c3)ncn2)c1F |
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| Structure | 
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