| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 4 |
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| Ligand | BDBM50615119 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2299693 |
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| IC50 | >80000±n/a nM |
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| Citation |  Kim, DR; Orr, MJ; Kwong, AJ; Deibler, KK; Munshi, HH; Bridges, CS; Chen, TJ; Zhang, X; Lacorazza, HD; Scheidt, KA Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett14:606-613 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 4 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 4 |
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| Synonyms: | JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44294.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1460558 |
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| Residue: | 399 |
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| Sequence: | MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
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| BDBM50615119 |
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| n/a |
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| Name | BDBM50615119 |
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| Synonyms: | CHEMBL5284723 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17ClN4O2 |
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| Mol. Mass. | 368.817 |
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| SMILES | ClCC(=O)Nc1cccc(Oc2cc(NCc3ccccc3)ncn2)c1 |
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| Structure | 
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