| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50202981 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_435551 (CHEMBL903910) |
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| IC50 | 18±n/a nM |
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| Citation |  Nozawa, D; Okubo, T; Ishii, T; Kakinuma, H; Chaki, S; Okuyama, S; Nakazato, A Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor. Bioorg Med Chem15:1989-2005 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50202981 |
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| n/a |
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| Name | BDBM50202981 |
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| Synonyms: | (+/-)-1-tert-butyl-4-(1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethyl)piperazine | CHEMBL226024 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H49FN4O |
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| Mol. Mass. | 560.7882 |
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| SMILES | COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)(C)C)c2ccc(F)cc2)CC1 |w:21.22| |
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| Structure | 
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