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TargetMacrophage metalloelastase
LigandBDBM50216172
Substrate/Competitorn/a
Meas. Tech.ChEMBL_439905 (CHEMBL890224)
IC50 121000±n/a nM
Citation Sasanelli, R; Boccarelli, A; Giordano, D; Laforgia, M; Arnesano, F; Natile, G; Cardellicchio, C; Capozzi, MA; Coluccia, M Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12. J Med Chem50:3434-41 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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  Blast E-value cutoff:
BDBM50216172
n/a
NameBDBM50216172
Synonyms:(Dichloro-phosphono-methyl)-phosphonic acid | CHEMBL12318 | bisphosphonate clodronate | clodronic acid
TypeSmall organic molecule
Emp. Form.CH4Cl2O6P2
Mol. Mass.244.892
SMILESOP(O)(=O)C(Cl)(Cl)P(O)(O)=O
Structure
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