Reaction Details | |||
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Target | Melanocortin receptor 5 | ||
Ligand | BDBM50217749 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_448695 (CHEMBL897841) | ||
Ki | 27000±n/a nM | ||
Citation | Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanocortin receptor 5 | |||
Name: | Melanocortin receptor 5 | ||
Synonyms: | MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R) | ||
Type: | Enzyme | ||
Mol. Mass.: | 36612.92 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P33032 | ||
Residue: | 325 | ||
Sequence: |
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BDBM50217749 | |||
n/a | |||
Name | BDBM50217749 | ||
Synonyms: | CHEMBL236020 | N-((Z)-2-chloro-3-phenyl-allyl)-N-[4-(4-guanidino-cyclohexylmethyl)-cyclohexyl]-4-(1H-indol-3-yl)-butyramide | ||
Type | Small organic molecule | ||
Emp. Form. | C35H46ClN5O | ||
Mol. Mass. | 588.226 | ||
SMILES | NC(N)=NC1CCC(CC2CCC(CC2)N(C\C(Cl)=C\c2ccccc2)C(=O)CCCc2c[nH]c3ccccc23)CC1 |(37.75,-39.73,;39.09,-40.5,;40.42,-39.74,;39.08,-42.05,;37.77,-42.88,;37.84,-44.42,;36.55,-45.24,;35.19,-44.53,;33.89,-45.37,;33.97,-46.9,;35.34,-47.61,;35.41,-49.14,;34.12,-49.98,;32.75,-49.28,;32.68,-47.74,;34.21,-51.51,;32.88,-52.45,;31.47,-51.64,;31.48,-50.01,;30.06,-52.44,;28.66,-51.62,;28.67,-50,;27.27,-49.18,;25.86,-49.99,;25.85,-51.62,;27.26,-52.43,;35.53,-52.26,;35.56,-53.78,;36.85,-51.47,;38.21,-52.22,;39.52,-51.42,;40.86,-52.17,;40.76,-53.71,;42.19,-54.29,;43.17,-53.1,;44.7,-53.04,;45.42,-51.69,;44.59,-50.39,;43.07,-50.45,;42.36,-51.8,;35.11,-43,;36.41,-42.17,)| | ||
Structure |