Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50217753

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_448693 (CHEMBL897839)

2100±n/a nM

Citation

Mutulis, F; Kreicberga, J; Yahorava, S; Mutule, I; Borisova-Jan, L; Yahorau, A; Muceniece, R; Azena, S; Veiksina, S; Petrovska, R; Wikberg, JE Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem15:5787-810 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50217753

n/a

Name

BDBM50217753

Synonyms:

CHEMBL235589 | N-(3-ethoxy-4-methoxybenzyl)-4-(2-(4-hydroxybenzyl)-1H-indol-3-yl)-N-(4-((4-aminocyclohexyl)methyl)cyclohexyl)butanamide

Type

Small organic molecule

Emp. Form.

C42H55N3O4

Mol. Mass.

665.9038

SMILES

CCOc1cc(CN(C2CCC(CC3CCC(N)CC3)CC2)C(=O)CCCc2c(Cc3ccc(O)cc3)[nH]c3ccccc23)ccc1OC |(26.76,-14.17,;26.76,-15.71,;28.09,-16.48,;28.09,-18.02,;29.42,-18.79,;29.42,-20.33,;30.75,-21.1,;32.08,-20.33,;32.08,-18.78,;33.43,-18,;33.44,-16.46,;32.09,-15.67,;32.1,-14.13,;33.44,-13.37,;34.77,-14.15,;36.1,-13.4,;36.11,-11.85,;37.45,-11.09,;34.78,-11.08,;33.44,-11.84,;30.74,-16.45,;30.74,-18.01,;33.43,-21.11,;33.43,-22.67,;34.77,-20.33,;36.1,-21.1,;37.44,-20.33,;38.77,-21.09,;39.35,-19.67,;38.54,-18.36,;39.26,-17,;40.8,-16.96,;41.52,-15.6,;40.71,-14.29,;41.43,-12.93,;39.16,-14.35,;38.44,-15.71,;40.89,-19.77,;41.26,-21.27,;42.61,-21.99,;42.66,-23.52,;41.35,-24.34,;40,-23.61,;39.95,-22.08,;28.09,-21.1,;26.76,-20.34,;26.76,-18.79,;25.42,-18.02,;25.43,-16.48,)|

Structure