Reaction Details |
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Target | Cathepsin B |
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Ligand | BDBM35509 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_440658 (CHEMBL889752) |
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IC50 | 690±n/a nM |
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Citation | Myers, MC; Napper, AD; Motlekar, N; Shah, PP; Chiu, CH; Beavers, MP; Diamond, SL; Huryn, DM; Smith, AB Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett17:4761-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin B |
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Name: | Cathepsin B |
Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
Type: | Enzyme |
Mol. Mass.: | 37819.69 |
Organism: | Homo sapiens (Human) |
Description: | gi_63102437 |
Residue: | 339 |
Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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BDBM35509 |
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n/a |
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Name | BDBM35509 |
Synonyms: | 2-thiophenecarboxylic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-3-pyrazolyl] ester | 5-amino-1-(4-methoxyphenylsulfonyl)-1H-pyrazol-3-yl thiophene-2-carboxylate | 5-amino-1-[(4-methoxyphenyl)sulfonyl]-1H-pyrazol-3-yl thiophene-2-carboxylate | CHEMBL243314 | MLS000086044 | SMR000021572 | [5-amino-1-(4-methoxyphenyl)sulfonylpyrazol-3-yl] thiophene-2-carboxylate | [5-azanyl-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] thiophene-2-carboxylate | cid_3240114 | thiophene-2-carboxylic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] ester |
Type | Small organic molecule |
Emp. Form. | C15H13N3O5S2 |
Mol. Mass. | 379.411 |
SMILES | COc1ccc(cc1)S(=O)(=O)n1nc(OC(=O)c2cccs2)cc1N |
Structure |
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