| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50219847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457263 (CHEMBL940859) |
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| IC50 | 19±n/a nM |
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| Citation |  Carter, PH; Brown, GD; Friedrich, SR; Cherney, RJ; Tebben, AJ; Lo, YC; Yang, G; Jezak, H; Solomon, KA; Scherle, PA; Decicco, CP Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2). Bioorg Med Chem Lett17:5455-61 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50219847 |
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| n/a |
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| Name | BDBM50219847 |
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| Synonyms: | (S)-N-(2-(3-(2,4-dimethylbenzylamino)-1-(tert-butylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-3-(ethylamino)-5-(trifluoromethyl)benzamide | CHEMBL392814 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H38F3N5O3 |
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| Mol. Mass. | 549.6282 |
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| SMILES | CCNc1cc(cc(c1)C(F)(F)F)C(=O)NCC(=O)N[C@@H](CNCc1ccc(C)cc1C)C(=O)NC(C)(C)C |
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| Structure | 
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