| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50222686 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_446484 (CHEMBL895596) |
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| IC50 | 49±n/a nM |
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| Citation |  Dressen, D; Garofalo, AW; Hawkinson, J; Hom, D; Jagodzinski, J; Marugg, JL; Neitzel, ML; Pleiss, MA; Szoke, B; Tung, JS; Wone, DW; Wu, J; Zhang, H Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists. J Med Chem50:5161-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50222686 |
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| n/a |
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| Name | BDBM50222686 |
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| Synonyms: | 5-(benzoylamino)-4-bromo-N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-1H-pyrazole-3-carboxamide | CHEMBL390272 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19BrN6O3 |
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| Mol. Mass. | 543.371 |
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| SMILES | Brc1c(NC(=O)c2ccccc2)n[nH]c1C(=O)NC1N=C(c2ccccc2)c2ccccc2NC1=O |w:18.19,t:21| |
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| Structure | 
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