| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 2 |
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| Ligand | BDBM50225787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_451581 (CHEMBL901788) |
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| IC50 | 2500±n/a nM |
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| Citation |  Davis, T; Bagley, MC; Dix, MC; Murziani, PG; Rokicki, MJ; Widdowson, CS; Zayed, JM; Bachler, MA; Kipling, D Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells. Bioorg Med Chem Lett17:6832-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 2 |
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| Name: | MAP kinase-activated protein kinase 2 |
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| Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45579.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49137 |
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| Residue: | 400 |
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| Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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| BDBM50225787 |
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| n/a |
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| Name | BDBM50225787 |
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| Synonyms: | 2,4-diamino-6,7-dihydroxy-10H-9-oxa-1-aza-anthracene-3-carbonitrile; TFA | CHEMBL1185204 | CHEMBL397819 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10N4O3 |
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| Mol. Mass. | 270.2435 |
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| SMILES | Nc1nc2Oc3cc(O)c(O)cc3Cc2c(N)c1C#N |
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| Structure | 
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