Reaction Details |
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Target | Metabotropic glutamate receptor 1 |
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Ligand | BDBM50177083 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_511021 (CHEMBL999637) |
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IC50 | 71±n/a nM |
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Citation | Nataraja Sekhar, Y; Ravikumar, M; Ravi Shashi Nayana, M; Mallena, SC; Kishore Kumar, M 3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1. Eur J Med Chem43:1025-34 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Metabotropic glutamate receptor 1 |
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Name: | Metabotropic glutamate receptor 1 |
Synonyms: | GRM1_RAT | Gprc1a | Grm1 | Metabotropic Glutamate 1a | Metabotropic glutamate receptor | Metabotropic glutamate receptor 1 | Mglur1 | metabotropic glutamate 1 | metabotropic glutamate 1/5-D | metabotropic glutamate 1/DA | metabotropic glutamate receptor 1 isoform alpha precursor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 133240.47 |
Organism: | RAT |
Description: | metabotropic glutamate 1/2 0 RAT::P23385 |
Residue: | 1199 |
Sequence: | MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE
KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI
EFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI
PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG
MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAM
AHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYD
IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGE
VSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFS
CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ
RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL
VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPAN
FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA
KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGG
RQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEE
DNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQ
QPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQ
HLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTAS
KLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
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BDBM50177083 |
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n/a |
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Name | BDBM50177083 |
Synonyms: | 3-(4-ethylphenyl)-9-[(2-methoxyethyl)(methyl)amino]pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one | 9-(2'-methoxyethylmethylamino)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one | CHEMBL225125 |
Type | Small organic molecule |
Emp. Form. | C21H22N4O2S |
Mol. Mass. | 394.49 |
SMILES | CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)CCOC)c23)c1=O |
Structure |
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