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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 1 | ||
| Ligand | BDBM50177072 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_511021 (CHEMBL999637) | ||
| IC50 | 140±n/a nM | ||
| Citation |  Nataraja Sekhar, Y; Ravikumar, M; Ravi Shashi Nayana, M; Mallena, SC; Kishore Kumar, M 3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1. Eur J Med Chem43:1025-34 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 1 | |||
| Name: | Metabotropic glutamate receptor 1 | ||
| Synonyms: | GRM1_RAT | Gprc1a | Grm1 | Metabotropic Glutamate 1a | Metabotropic glutamate receptor | Metabotropic glutamate receptor 1 | Mglur1 | metabotropic glutamate 1 | metabotropic glutamate 1/5-D | metabotropic glutamate 1/DA | metabotropic glutamate receptor 1 isoform alpha precursor | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 133240.47 | ||
| Organism: | RAT | ||
| Description: | metabotropic glutamate 1/2 0 RAT::P23385 | ||
| Residue: | 1199 | ||
| Sequence: |
| ||
| BDBM50177072 | |||
| n/a | |||
| Name | BDBM50177072 | ||
| Synonyms: | 9-Dimethylamino-3-(4-methyl-cyclohexyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one | 9-dimethylamino-3-(4-methylcyclohexyl)-3H-5-thia-1,3,6-triazafluoren-4-one | CHEMBL224315 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22N4OS | ||
| Mol. Mass. | 342.458 | ||
| SMILES | CC1CCC(CC1)n1cnc2c(sc3nccc(N(C)C)c23)c1=O |(5.87,-19.78,;4.34,-19.93,;3.7,-21.33,;2.18,-21.48,;1.29,-20.23,;1.91,-18.82,;3.44,-18.68,;-.24,-20.38,;-1.15,-19.13,;-2.7,-19.28,;-3.32,-20.7,;-2.41,-21.95,;-3.32,-23.19,;-4.79,-22.72,;-6.12,-23.49,;-7.45,-22.72,;-7.45,-21.18,;-6.12,-20.41,;-6.13,-18.87,;-4.8,-18.1,;-7.46,-18.11,;-4.79,-21.17,;-.88,-21.79,;.02,-23.04,)| | ||
| Structure | 
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