Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50245302 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_511068 (CHEMBL1000360) | ||
IC50 | 67±n/a nM | ||
Citation | Smaill, JB; Baker, EN; Booth, RJ; Bridges, AJ; Dickson, JM; Dobrusin, EM; Ivanovic, I; Kraker, AJ; Lee, HH; Lunney, EA; Ortwine, DF; Palmer, BD; Quin, J; Squire, CJ; Thompson, AM; Denny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50245302 | |||
n/a | |||
Name | BDBM50245302 | ||
Synonyms: | 4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(phenylamino)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL461134 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H21Cl2N3O3 | ||
Mol. Mass. | 530.401 | ||
SMILES | Oc1ccc2n(CCCNc3ccccc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(17.36,-29.28,;18.7,-30.05,;18.69,-31.6,;20.03,-32.37,;21.37,-31.6,;22.85,-32.07,;23.33,-33.53,;22.31,-34.68,;22.8,-36.14,;21.78,-37.29,;22.26,-38.76,;21.24,-39.9,;21.72,-41.36,;23.23,-41.67,;24.26,-40.51,;23.77,-39.05,;23.75,-30.81,;25.28,-30.64,;25.9,-29.22,;24.97,-27.98,;25.28,-26.47,;26.69,-25.84,;23.95,-25.71,;22.81,-26.75,;21.31,-26.44,;23.45,-28.15,;22.83,-29.56,;21.36,-30.05,;20.02,-29.28,;27.43,-29.04,;28.34,-30.29,;27.73,-31.7,;29.87,-30.11,;30.49,-28.7,;29.56,-27.46,;28.04,-27.64,;28.02,-26.09,)| | ||
Structure |