Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50245178 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_511068 (CHEMBL1000360) | ||
IC50 | 59±n/a nM | ||
Citation | Smaill, JB; Baker, EN; Booth, RJ; Bridges, AJ; Dickson, JM; Dobrusin, EM; Ivanovic, I; Kraker, AJ; Lee, HH; Lunney, EA; Ortwine, DF; Palmer, BD; Quin, J; Squire, CJ; Thompson, AM; Denny, WA Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem43:1276-96 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50245178 | |||
n/a | |||
Name | BDBM50245178 | ||
Synonyms: | 6-(3-(1H-imidazol-1-yl)propyl)-4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL452829 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H18Cl2N4O3 | ||
Mol. Mass. | 505.352 | ||
SMILES | Oc1ccc2n(CCCn3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(17.41,2.71,;18.74,1.94,;18.74,.39,;20.07,-.38,;21.42,.39,;22.89,-.08,;23.38,-1.54,;22.36,-2.69,;22.84,-4.15,;21.82,-5.3,;22.15,-6.81,;20.82,-7.59,;19.67,-6.57,;20.29,-5.15,;23.79,1.18,;25.33,1.35,;25.95,2.77,;25.02,4.01,;25.33,5.52,;26.73,6.15,;24,6.28,;22.86,5.24,;21.35,5.55,;23.49,3.84,;22.88,2.43,;21.41,1.94,;20.07,2.71,;27.48,2.95,;28.39,1.7,;27.78,.29,;29.92,1.88,;30.53,3.29,;29.61,4.53,;28.08,4.35,;28.07,5.9,)| | ||
Structure |