| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM7126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519498 (CHEMBL951804) |
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| IC50 | 224±n/a nM |
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| Citation |  Mascarenhas, NM; Ghoshal, N An efficient tool for identifying inhibitors based on 3D-QSAR and docking using feature-shape pharmacophore of biologically active conformation--a case study with CDK2/cyclinA. Eur J Med Chem43:2807-18 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM7126 |
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| n/a |
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| Name | BDBM7126 |
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| Synonyms: | 3-Propylaminopyrazole deriv. 3 | CHEMBL112442 | CS2 | N-(5-Cyclopropyl-1H-pyrazol-3-yl)butanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N3O |
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| Mol. Mass. | 193.2456 |
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| SMILES | CCCC(=O)Nc1cc([nH]n1)C1CC1 |
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| Structure | 
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