| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid type B receptor subunit 1 |
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| Ligand | BDBM50211642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_554602 (CHEMBL964516) |
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| EC50 | 500000±n/a nM |
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| Citation |  Kumar, RJ; Chebib, M; Hibbs, DE; Kim, HL; Johnston, GA; Salam, NK; Hanrahan, JR Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem51:3825-40 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid type B receptor subunit 1 |
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| Name: | Gamma-aminobutyric acid type B receptor subunit 1 |
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| Synonyms: | GABA-B receptor | GABA-B receptor 1 | GABA-B-R1 | GABA-BR1 | GABBR1 | GABR1_HUMAN | GARABR1 | GPRC3A | Gb1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 108337.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UBS5 |
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| Residue: | 961 |
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| Sequence: | MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVD
YEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLP
ALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSG
GWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKI
ILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKL
FEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDAR
IIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE
GHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALA
LNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIE
QLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSS
LGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFP
FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM
DVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLL
LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLA
IVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEK
IIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLY
K
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| BDBM50211642 |
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| n/a |
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| Name | BDBM50211642 |
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| Synonyms: | CHEMBL397209 | Methyl(1,2,3,6-tetrahydropyridinium-4-yl)phosphinate | methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C6H12NO2P |
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| Mol. Mass. | 161.1387 |
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| SMILES | CP(O)(=O)C1=CCNCC1 |t:4| |
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| Structure | 
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