| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor p65 |
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| Ligand | BDBM50252374 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491743 (CHEMBL950546) |
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| EC50 | 12000±n/a nM |
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| Citation |  Whitson, EL; Bugni, TS; Chockalingam, PS; Concepcion, GP; Harper, MK; He, M; Hooper, JN; Mangalindan, GC; Ritacco, F; Ireland, CM Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp. J Nat Prod71:1213-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor p65 |
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| Name: | Transcription factor p65 |
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| Synonyms: | NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60211.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q04206 |
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| Residue: | 551 |
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| Sequence: | MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
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| BDBM50252374 |
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| n/a |
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| Name | BDBM50252374 |
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| Synonyms: | CHEMBL475118 | Spheciosterol sulfate B |
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| Type | Small organic molecule |
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| Emp. Form. | C31H49O13S3 |
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| Mol. Mass. | 725.91 |
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| SMILES | CC(C)C(CC[C@@H](C)[C@H]1CC[C@@]2(C)[C@@H]3C[C@H](OS([O-])(=O)=O)[C@H]4[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](C[C@]4(C)C3=CC[C@]12C)OS([O-])(=O)=O)C(C)=C |r,c:36| |
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| Structure | 
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