| Reaction Details |
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 | Report a problem with these data |
| Target | Nischarin |
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| Ligand | BDBM50272778 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_514509 (CHEMBL973551) |
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| IC50 | 211600±n/a nM |
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| Citation |  Gentili, F; Cardinaletti, C; Vesprini, C; Ghelfi, F; Farande, A; Giannella, M; Piergentili, A; Quaglia, W; Mattioli, L; Perfumi, M; Hudson, A; Pigini, M Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions. J Med Chem51:5130-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nischarin |
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| Name: | Nischarin |
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| Synonyms: | Imidazoline I1 | NISCH_RAT | Nisch | Nischarin |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 166460.59 |
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| Organism: | RAT |
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| Description: | Q4G017 |
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| Residue: | 1502 |
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| Sequence: | MAAATLSFGPEREAEPAKEARVVGSELVDTYTVYVIQVTDGNHEWTIKHRYSDFHDLHEK
LVAERKIDKTLLPPKKIIGKNSRSLVEKREKDLEVYLQTLLKTFPDVAPRVLAHFLHFHL
YEINGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGH
ILDFTCRLKYLKVSGTEGPFGTSNIREQLLPFDLSIFKSLHQVEMSHCDAKHVRGLVTSK
PTLATMSVRFSAASMKEVLVPEASEFDEWEPEGTTLGGPVTAVIPTWQALTTLDLSHNSI
SEIDESVKLIPKIEYLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVKT
LNLAGNFLERLSGLHKLYSLVNLDLRDNRIEQLDEVKSIGNLPCLEHVALLNNPLSIIPD
YRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKSKLSSTEKKVGEDFRL
PTAPCIRPSSSPPTAVPTSASLPQPILSNQGIMFVQEEALASSLSSTDSLPPDDRPIAQA
CSNSMGSLPTGQVAAEDLRDLPGAVGGVSPDHAEPEVQVVPGSGQIIFLPFTCIGYTATN
QDFIQRLSTLIRQAIERQLPAWIEAANQREEAHGEQGEEEEEEEEEDVAESRYFEMGPPD
AEEEEGSGQGEEDEEDEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSI
RQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVL
KVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFY
KVAGGSQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAVK
SAAIPYWLLLTSQHLNVIKADFNPMPSRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQP
RGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLKDLKTVVIAKNPSARPR
TQGPLAGGQPAKSRVSAEQRLQETPAEAPAPAPAAAESAAEAPAAAEASAPAGAPAPAGA
PAPAGAPAGAQAPAPAQAEVPAQYPSERLIQSTSEENQIPSHLPVCPSLQHIARLRGRAI
IDLFHSSIAEVENEELRHLLWSSVVFYQTPGLEVTACVLLSTKAVYFILHDGLRRYFSEP
LQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQYFRLTGSSPTQVVTCLTRDS
YLTHCFLQHLMLVLSSLERTPSPEPIDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSE
EEVGDLTYVVAQKMADPAKNPALSILLYIQAFQVITPQLGRGRGPLRPKTLLLTSAEIFL
LDEDYIHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYNPYPQALTLVFDDTQGHDL
MGSVTLDHFGEMPGGPGRAGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVEL
TG
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| BDBM50272778 |
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| n/a |
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| Name | BDBM50272778 |
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| Synonyms: | 3-[2-(4,5-Dihydro-1H-imidazol-2-yl)-ethyl]-pyridine | CHEMBL452401 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13N3 |
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| Mol. Mass. | 175.2303 |
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| SMILES | C(Cc1cccnc1)C1=NCCN1 |t:9| |
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| Structure | 
|
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