Reaction Details | |||
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Target | Tyrosine-protein phosphatase non-receptor type 1 | ||
Ligand | BDBM50079577 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_557715 (CHEMBL963010) | ||
IC50 | 3370±n/a nM | ||
Citation | Zhang, YN; Zhang, W; Hong, D; Shi, L; Shen, Q; Li, JY; Li, J; Hu, LH Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities. Bioorg Med Chem16:8697-705 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein phosphatase non-receptor type 1 | |||
Name: | Tyrosine-protein phosphatase non-receptor type 1 | ||
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) | ||
Type: | Protein phosphatase | ||
Mol. Mass.: | 49963.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Human recombinant GST-fusion PTP1B (1-435). | ||
Residue: | 435 | ||
Sequence: |
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BDBM50079577 | |||
n/a | |||
Name | BDBM50079577 | ||
Synonyms: | (4aS,6aS,6bR,10S,12aR,14bS)-10-Hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid | (4aS,6aS,6bR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | CHEMBL168 | oleanolic acid | ||
Type | Small organic molecule | ||
Emp. Form. | C30H48O3 | ||
Mol. Mass. | 456.7003 | ||
SMILES | CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]34C)[C@@H]2C1)C(O)=O |c:10| | ||
Structure |