| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
|---|
| Ligand | BDBM50264675 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_535277 (CHEMBL981736) |
|---|
| EC50 | 3.2±n/a nM |
|---|
| Citation |  Nakajima, Y; Imanishi, M; Itou, S; Hamashima, H; Tomishima, Y; Washizuka, K; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Hattori, K Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV. Bioorg Med Chem Lett18:5037-40 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-3 adrenergic receptor |
|---|
| Name: | Beta-3 adrenergic receptor |
|---|
| Synonyms: | ADRB3 | ADRB3_CANLF | B3AR |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 43072.49 |
|---|
| Organism: | Canis familiaris |
|---|
| Description: | ChEMBL_497812 |
|---|
| Residue: | 405 |
|---|
| Sequence: | MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIV
AIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRV
GADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRR
ELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGT
FTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS
|
|
|
|---|
| BDBM50264675 |
|---|
| n/a |
|---|
| Name | BDBM50264675 |
|---|
| Synonyms: | (R)-5-(3-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethyl)phenoxy)-2-isopropoxybenzoic acid | CHEMBL523265 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28ClNO5 |
|---|
| Mol. Mass. | 469.957 |
|---|
| SMILES | CC(C)Oc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
