| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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| Ligand | BDBM26526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_492682 (CHEMBL953112) |
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| Ki | 0.560000±n/a nM |
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| Citation |  Georgiadis, D; Yiotakis, A Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem16:8781-94 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 17 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
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| Synonyms: | A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme |
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| Type: | Metalloprotease |
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| Mol. Mass.: | 12197.99 |
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| Organism: | Sus scrofa (pig) |
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| Description: | Partially purified TACE was obtained from porcine spleen. |
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| Residue: | 112 |
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| Sequence: | MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
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| BDBM26526 |
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| n/a |
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| Name | BDBM26526 |
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| Synonyms: | (2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide | BMCL181958 Compound 1 | CHEMBL148169 | IK682 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N3O4 |
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| Mol. Mass. | 433.4996 |
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| SMILES | C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO |r| |
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| Structure | 
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