Reaction Details |
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Target | Glycogen phosphorylase, muscle form |
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Ligand | BDBM50263824 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_535893 (CHEMBL983534) |
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Ki | 28000±n/a nM |
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Citation | Somsák, L; Nagy, V; Vidal, S; Czifrák, K; Berzsényi, E; Praly, JP Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent. Bioorg Med Chem Lett18:5680-3 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen phosphorylase, muscle form |
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Name: | Glycogen phosphorylase, muscle form |
Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
Type: | Enzyme |
Mol. Mass.: | 97296.32 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
Residue: | 843 |
Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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BDBM50263824 |
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n/a |
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Name | BDBM50263824 |
Synonyms: | (1S)-1,5-Anhydro-D-glucitol-spiro[1.5]-3-(4-fluorophenyl)-1,4,2-oxathiazole | (5S,7R,8S,9S,10R)-3-(4-Fluoro-phenyl)-7-hydroxymethyl-1,6-dioxa-4-thia-2-aza-spiro[4.5]dec-2-ene-8,9,10-triol | CHEMBL489972 |
Type | Small organic molecule |
Emp. Form. | C13H14FNO6S |
Mol. Mass. | 331.317 |
SMILES | OC[C@H]1O[C@]2(ON=C(S2)c2ccc(F)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r,c:6| |
Structure |
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