Reaction Details |
| Report a problem with these data |
Target | Hormone-sensitive lipase |
---|
Ligand | BDBM50147251 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_538751 (CHEMBL1024870) |
---|
IC50 | 2±n/a nM |
---|
Citation | Taha, MO; Dahabiyeh, LA; Bustanji, Y; Zalloum, H; Saleh, S Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors. J Med Chem51:6478-94 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hormone-sensitive lipase |
---|
Name: | Hormone-sensitive lipase |
Synonyms: | Hormone-sensitive lipase | Hormone-sensitive lipase (HSL) | LIPS_RAT | Lipe |
Type: | Enzyme |
Mol. Mass.: | 116814.94 |
Organism: | Rattus norvegicus (Rat) |
Description: | P15304 |
Residue: | 1068 |
Sequence: | MKPRRPISFTREITAMEPSSTSVSRPEWRPEAQQTLTDYPGSRELQEFGIPQKQSLPNEA
TAQQGAEFQQEQGVQQSTLLQKLLTPLAFPVPQQSFPSHKVHSDQQEATSQNGPGAGKVH
TTQKELEHRDEHVGTAESGPAEPPPATEVEATSIAQAVSGPDKKLPTQTDLVSQERAEQS
DPTAQQTPLVQGVKSDQGSLIESGILARLQKLAIQQPSQEWKTFLDCVTESDMEKYLNSS
SKSNPPEPSGGTVIPGTLPSKQKPDCGKMSGYGGKLPHGKKGILQKHKHYWDTASAFSHS
MDLRTMTQSLVALAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHH
FDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRASHNLAELEAYLAALTQ
LRALAYYAQRLLTINRPGVLFFEGDEGLSADFLQDYVTLHKGCFYGRCLGFQFTPAIRPF
LQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKA
FWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPV
LARLISYDLREGQDSKMLNSLAKSEGPRLELRPRPQQAPRSRALVVHIHGGGFVAQTSKS
HEPYLKNWAQELGVPIISIDYSLAPEAPFPRALEECFFAYCWAVKHCELLGSTGERICLA
GDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSK
CVSAYSGTETEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPHKT
PLPATETLRPTDSGRLTESMRRSVSEAALAQPEGLLGTDSLKKLTIKDLSFKGNSEPSDS
PEMSQSMETLGPSTPSDVNFFLRSGNSQEEAETRDDISPMDGIPRVRAAFPDGFHPRRSS
QGVLHMPLYSSPIVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLG
QPVTLKVVEDLPHGFLSLAALCRETRQAAELCVQRIRLILTPPAAPLT
|
|
|
BDBM50147251 |
---|
n/a |
---|
Name | BDBM50147251 |
Synonyms: | 4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxylic acid methyl-thiophen-2-ylmethyl-amide | 4-isopropyl-N,3-dimethyl-5-oxo-N-(thiophen-2-ylmethyl)isoxazole-2(5H)-carboxamide | CHEMBL107197 |
Type | Small organic molecule |
Emp. Form. | C14H18N2O3S |
Mol. Mass. | 294.369 |
SMILES | CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1cccs1 |
Structure |
|