| Reaction Details |
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 | Report a problem with these data |
| Target | Hormone-sensitive lipase |
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| Ligand | BDBM50147280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_538751 (CHEMBL1024870) |
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| IC50 | 6±n/a nM |
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| Citation |  Taha, MO; Dahabiyeh, LA; Bustanji, Y; Zalloum, H; Saleh, S Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors. J Med Chem51:6478-94 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hormone-sensitive lipase |
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| Name: | Hormone-sensitive lipase |
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| Synonyms: | Hormone-sensitive lipase | Hormone-sensitive lipase (HSL) | LIPS_RAT | Lipe |
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| Type: | Enzyme |
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| Mol. Mass.: | 116814.94 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P15304 |
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| Residue: | 1068 |
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| Sequence: | MKPRRPISFTREITAMEPSSTSVSRPEWRPEAQQTLTDYPGSRELQEFGIPQKQSLPNEA
TAQQGAEFQQEQGVQQSTLLQKLLTPLAFPVPQQSFPSHKVHSDQQEATSQNGPGAGKVH
TTQKELEHRDEHVGTAESGPAEPPPATEVEATSIAQAVSGPDKKLPTQTDLVSQERAEQS
DPTAQQTPLVQGVKSDQGSLIESGILARLQKLAIQQPSQEWKTFLDCVTESDMEKYLNSS
SKSNPPEPSGGTVIPGTLPSKQKPDCGKMSGYGGKLPHGKKGILQKHKHYWDTASAFSHS
MDLRTMTQSLVALAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHH
FDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRASHNLAELEAYLAALTQ
LRALAYYAQRLLTINRPGVLFFEGDEGLSADFLQDYVTLHKGCFYGRCLGFQFTPAIRPF
LQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKA
FWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPV
LARLISYDLREGQDSKMLNSLAKSEGPRLELRPRPQQAPRSRALVVHIHGGGFVAQTSKS
HEPYLKNWAQELGVPIISIDYSLAPEAPFPRALEECFFAYCWAVKHCELLGSTGERICLA
GDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSK
CVSAYSGTETEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPHKT
PLPATETLRPTDSGRLTESMRRSVSEAALAQPEGLLGTDSLKKLTIKDLSFKGNSEPSDS
PEMSQSMETLGPSTPSDVNFFLRSGNSQEEAETRDDISPMDGIPRVRAAFPDGFHPRRSS
QGVLHMPLYSSPIVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLG
QPVTLKVVEDLPHGFLSLAALCRETRQAAELCVQRIRLILTPPAAPLT
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| BDBM50147280 |
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| n/a |
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| Name | BDBM50147280 |
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| Synonyms: | 3-Methyl-2-(4-methyl-piperidine-1-carbonyl)-4-(tetrahydro-thiopyran-4-yl)-2H-isoxazol-5-one | 3-methyl-2-(4-methylpiperidine-1-carbonyl)-4-(tetrahydro-2H-thiopyran-4-yl)isoxazol-5(2H)-one | CHEMBL108325 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H24N2O3S |
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| Mol. Mass. | 324.438 |
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| SMILES | CC1CCN(CC1)C(=O)n1oc(=O)c(C2CCSCC2)c1C |
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| Structure | 
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