| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stromelysin-1 |
|---|
| Ligand | BDBM50241177 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_518964 (CHEMBL941552) |
|---|
| IC50 | 28000±n/a nM |
|---|
| Citation |  Bailey, S; Fish, PV; Billotte, S; Bordner, J; Greiling, D; James, K; McElroy, A; Mills, JE; Reed, C; Webster, R Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg Med Chem Lett18:6562-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stromelysin-1 |
|---|
| Name: | Stromelysin-1 |
|---|
| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53973.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08254 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
|
|
|
|---|
| BDBM50241177 |
|---|
| n/a |
|---|
| Name | BDBM50241177 |
|---|
| Synonyms: | (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide | 5-{(1R)-4-cyclohexyl-1-[2-(hydroxylamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide | CHEMBL226686 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H28N4O4 |
|---|
| Mol. Mass. | 352.4286 |
|---|
| SMILES | CN(C)C(=O)c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
