| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Secreted frizzled-related protein 1 |
|---|
| Ligand | BDBM50265549 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_560813 (CHEMBL1011781) |
|---|
| IC50 | 50±n/a nM |
|---|
| Citation |  Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem52:105-16 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Secreted frizzled-related protein 1 |
|---|
| Name: | Secreted frizzled-related protein 1 |
|---|
| Synonyms: | FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35404.91 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1363191 |
|---|
| Residue: | 314 |
|---|
| Sequence: | MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVD
IPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPV
CLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKP
QGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKK
KDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKK
MKNHECPTFQSVFK
|
|
|
|---|
| BDBM50265549 |
|---|
| n/a |
|---|
| Name | BDBM50265549 |
|---|
| Synonyms: | CHEMBL507695 | N-{1-[1-(Cyclohexylcarbonyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H36F3N3O6S2 |
|---|
| Mol. Mass. | 655.749 |
|---|
| SMILES | FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)C1CCCCC1)S(=O)(=O)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
