| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM50247757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_495008 (CHEMBL997738) |
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| IC50 | 415700±n/a nM |
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| Citation |  Gökhan-Kelekçi, N; Koyunoqlu, S; Yabanoqlu, S; Yesilada, K; Ozgen, O; Uçar, G; Erol, K; Kendi, E; Yesilada, A New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. Bioorg Med Chem17:675-89 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58469.65 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P19643 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
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| BDBM50247757 |
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| n/a |
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| Name | BDBM50247757 |
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| Synonyms: | 2-[(3-Phenyl-5'-(4-chlorophenyl)-2'-pyrazoline-1-yl]-3-methyl-4(3H)-quinazolinone | CHEMBL461789 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19ClN4O |
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| Mol. Mass. | 414.887 |
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| SMILES | Cn1c(nc2ccccc2c1=O)N1N=C(CC1c1ccc(Cl)cc1)c1ccccc1 |c:15| |
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| Structure | 
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