Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM50255852 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_515268 (CHEMBL991292) |
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IC50 | 730±n/a nM |
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Citation | Smil, DV; Manku, S; Chantigny, YA; Leit, S; Wahhab, A; Yan, TP; Fournel, M; Maroun, C; Li, Z; Lemieux, AM; Nicolescu, A; Rahil, J; Lefebvre, S; Panetta, A; Besterman, JM; Déziel, R Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett19:688-92 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM50255852 |
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n/a |
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Name | BDBM50255852 |
Synonyms: | 4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | CHEMBL481538 |
Type | Small organic molecule |
Emp. Form. | C23H21N3O4 |
Mol. Mass. | 403.4305 |
SMILES | ONC(=O)c1ccc(CN2[C@H](Cc3ccc(O)cc3)C(=O)Nc3ccccc23)cc1 |r| |
Structure |
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