| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50257658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562452 (CHEMBL1010955) |
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| IC50 | 180±n/a nM |
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| Citation |  Koltun, DO; Parkhill, EQ; Vasilevich, NI; Glushkov, AI; Zilbershtein, TM; Ivanov, AV; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett19:2048-52 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50257658 |
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| n/a |
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| Name | BDBM50257658 |
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| Synonyms: | CHEMBL492498 | N-(2-(2-(4-methoxyphenyl)-3-oxo-6-((4-(trifluoromethyl)pyridin-2-yl)methylamino)pyrido[2,3-b]pyrazin-4(3H)-yl)ethyl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23F3N6O3 |
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| Mol. Mass. | 512.4837 |
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| SMILES | COc1ccc(cc1)-c1nc2ccc(NCc3cc(ccn3)C(F)(F)F)nc2n(CCNC(C)=O)c1=O |
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| Structure | 
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