| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA 6-desaturase |
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| Ligand | BDBM50257808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562450 (CHEMBL1010953) |
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| IC50 | >30±n/a nM |
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| Citation |  Koltun, DO; Parkhill, EQ; Vasilevich, NI; Glushkov, AI; Zilbershtein, TM; Ivanov, AV; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett19:2048-52 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA 6-desaturase |
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| Name: | Acyl-CoA 6-desaturase |
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| Synonyms: | FADS2_RAT | Fads2 | Fadsd6 | Fatty acid desaturase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52399.93 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_852950 |
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| Residue: | 444 |
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| Sequence: | MGKGGNQGEGSTELQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVI
GHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTA
EDMNLFKTNHLFFFLLLSHIIVMESIAWFILSYFGNGWIPTVITAFVLATSQAQAGWLQH
DYGHLSVYKKSIWNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFV
LGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIRRRDWVDLAWAI
SYYARFFYTYIPFYGILGALVFLNFIRFLESHWFVWVTQMNHIVMEIDLDHYRDWFSSQL
AATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLL
RALLDIVSSLKKSGELWLDAYLHK
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| BDBM50257808 |
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| n/a |
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| Name | BDBM50257808 |
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| Synonyms: | CHEMBL495001 | N-(2-(6-(3,4-dichlorobenzylamino)-3-oxo-2-(pyridin-3-yl)pyrido[2,3-b]pyrazin-4(3H)-yl)ethyl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20Cl2N6O2 |
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| Mol. Mass. | 483.35 |
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| SMILES | CC(=O)NCCn1c2nc(NCc3ccc(Cl)c(Cl)c3)ccc2nc(-c2cccnc2)c1=O |
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| Structure | 
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