Reaction Details |
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Target | 5-hydroxytryptamine receptor 3A |
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Ligand | BDBM50413523 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_564428 (CHEMBL964233) |
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Ki | 316.23±n/a nM |
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Citation | Lemaître, S; Lepailleur, A; Bureau, R; Butt-Gueulle, S; Lelong-Boulouard, V; Duchatelle, P; Boulouard, M; Dumuis, A; Daveu, C; Lezoualc'h, F; Pfeiffer, B; Dauphin, F; Rault, S Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. Bioorg Med Chem17:2607-22 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 3A |
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Name: | 5-hydroxytryptamine receptor 3A |
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 |
Type: | Protein |
Mol. Mass.: | 55283.27 |
Organism: | Homo sapiens (Human) |
Description: | P46098 |
Residue: | 478 |
Sequence: | MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
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BDBM50413523 |
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n/a |
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Name | BDBM50413523 |
Synonyms: | CHEMBL470195 |
Type | Small organic molecule |
Emp. Form. | C17H22N4O3 |
Mol. Mass. | 330.3816 |
SMILES | COc1ccc2[nH]c(=O)n(C(=O)NC3C[C@@H]4CC[C@@H](C3)N4C)c2c1 |r,TLB:12:13:20:16.17| |
Structure |
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