Reaction Details |
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Target | Caspase-7 |
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Ligand | BDBM50257422 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_562696 (CHEMBL1012731) |
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IC50 | 135±n/a nM |
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Citation | Podichetty, AK; Faust, A; Kopka, K; Wagner, S; Schober, O; Schäfers, M; Haufe, G Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors. Bioorg Med Chem17:2680-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-7 |
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Name: | Caspase-7 |
Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
Type: | Enzyme |
Mol. Mass.: | 34273.91 |
Organism: | Homo sapiens (Human) |
Description: | P55210 |
Residue: | 303 |
Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
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BDBM50257422 |
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n/a |
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Name | BDBM50257422 |
Synonyms: | (S)-3,5-Bis-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin | CHEMBL493127 |
Type | Small organic molecule |
Emp. Form. | C23H20F6N2O5S |
Mol. Mass. | 550.471 |
SMILES | COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)C(=O)c2c1 |r| |
Structure |
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