| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-7 |
|---|
| Ligand | BDBM50257480 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_562696 (CHEMBL1012731) |
|---|
| IC50 | 5640±n/a nM |
|---|
| Citation |  Podichetty, AK; Faust, A; Kopka, K; Wagner, S; Schober, O; Schäfers, M; Haufe, G Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors. Bioorg Med Chem17:2680-8 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-7 |
|---|
| Name: | Caspase-7 |
|---|
| Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 34273.91 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P55210 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
|
|
|
|---|
| BDBM50257480 |
|---|
| n/a |
|---|
| Name | BDBM50257480 |
|---|
| Synonyms: | (S)-3,3-Difluoro-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]indolin-2-one | CHEMBL494539 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H23F3N2O3S |
|---|
| Mol. Mass. | 392.436 |
|---|
| SMILES | COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(CCCF)CC(F)(F)c2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
