| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50259259 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_499366 (CHEMBL1015818) |
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| IC50 | 2580±n/a nM |
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| Citation |  Koltun, DO; Vasilevich, NI; Parkhill, EQ; Glushkov, AI; Zilbershtein, TM; Mayboroda, EI; Boze, MA; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Chu, N; Hao, J; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett19:3050-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41485.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07308 |
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| Residue: | 358 |
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| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
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| BDBM50259259 |
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| n/a |
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| Name | BDBM50259259 |
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| Synonyms: | CHEMBL466889 | N-(3-(4-chlorobenzyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)-2-hydroxyacetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13ClN4O3 |
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| Mol. Mass. | 344.752 |
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| SMILES | OCC(=O)Nc1cnc2ncn(Cc3ccc(Cl)cc3)c(=O)c2c1 |
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| Structure | 
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