| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
|---|
| Ligand | BDBM50259133 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_499367 (CHEMBL1015819) |
|---|
| IC50 | 790±n/a nM |
|---|
| Citation |  Koltun, DO; Vasilevich, NI; Parkhill, EQ; Glushkov, AI; Zilbershtein, TM; Mayboroda, EI; Boze, MA; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Chu, N; Hao, J; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett19:3050-3 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stearoyl-CoA desaturase |
|---|
| Name: | Stearoyl-CoA desaturase |
|---|
| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41537.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00767 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
|
|
|
|---|
| BDBM50259133 |
|---|
| n/a |
|---|
| Name | BDBM50259133 |
|---|
| Synonyms: | CHEMBL466719 | benzyl 3-(3,4-dimethylbenzyl)-4-oxo-3,4-dihydroquinazolin-6-ylcarbamate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23N3O3 |
|---|
| Mol. Mass. | 413.4684 |
|---|
| SMILES | Cc1ccc(Cn2cnc3ccc(NC(=O)OCc4ccccc4)cc3c2=O)cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
