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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | ATP-dependent translocase ABCB1 | ||
| Ligand | BDBM50249730 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_498556 (CHEMBL974429) | ||
| IC50 | 6800±n/a nM | ||
| Citation |  Gannon, MK; Holt, JJ; Bennett, SM; Wetzel, BR; Loo, TW; Bartlett, MC; Clarke, DM; Sawada, GA; Higgins, JW; Tombline, G; Raub, TJ; Detty, MR Rhodamine inhibitors of P-glycoprotein: an amide/thioamide"switch" for ATPase activity. J Med Chem52:3328-41 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| ATP-dependent translocase ABCB1 | |||
| Name: | ATP-dependent translocase ABCB1 | ||
| Synonyms: | ABCB1 | MDR1 | MDR1_HUMAN | Multidrug Resistance Transporter MDR 1 | Multidrug resistance protein 1 | Multidrug resistance protein 1/Multidrug resistance associated protein 1 | P-glycoprotein (P-gp) | P-glycoprotein 1 | PGY1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 141503.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08183 | ||
| Residue: | 1280 | ||
| Sequence: |
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| BDBM50249730 | |||
| n/a | |||
| Name | BDBM50249730 | ||
| Synonyms: | 12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(4-N,N-dimethylaminophenyl)-1H,5Hselenoxantheno[2,3,4-ij]quinolizin-14-ium Hexafluorophosphate | CHEMBL491577 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H32N3Se | ||
| Mol. Mass. | 501.54 | ||
| SMILES | CN(C)c1ccc(cc1)-c1c2ccc(cc2[se]c2c3CCCN4CCCc(cc12)c34)=[N+](C)C |(17.95,-43.48,;16.62,-44.26,;15.29,-43.49,;16.63,-45.8,;15.29,-46.58,;15.3,-48.11,;16.63,-48.87,;17.97,-48.1,;17.96,-46.57,;16.64,-50.41,;17.99,-51.18,;19.33,-50.4,;20.68,-51.16,;20.7,-52.73,;19.35,-53.52,;17.99,-52.75,;16.65,-53.52,;15.31,-52.75,;13.97,-53.52,;13.97,-55.06,;12.63,-55.83,;11.3,-55.05,;11.3,-53.51,;9.97,-52.74,;9.97,-51.2,;11.3,-50.43,;12.64,-51.21,;13.97,-50.43,;15.3,-51.19,;12.63,-52.75,;22.03,-53.49,;22.04,-55.03,;23.36,-52.71,)| | ||
| Structure | 
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