| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50258658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519763 (CHEMBL939026) |
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| EC50 | 6210±n/a nM |
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| Citation |  Bridges, TM; Marlo, JE; Niswender, CM; Jones, CK; Jadhav, SB; Gentry, PR; Plumley, HC; Weaver, CD; Conn, PJ; Lindsley, CW Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem52:3445-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50258658 |
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| n/a |
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| Name | BDBM50258658 |
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| Synonyms: | 5-fluoro-1-(2-(trifluoromethyl)benzyl)indoline-2,3-dione | CHEMBL467281 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H9F4NO2 |
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| Mol. Mass. | 323.2418 |
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| SMILES | Fc1ccc2N(Cc3ccccc3C(F)(F)F)C(=O)C(=O)c2c1 |
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| Structure | 
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